Can carnitine cause insomnia? Wu X, Huang W, Prasad PD, et al. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. Karimi, M., Mohammadi, F., Behmanesh, F., Samani, S. M., Borzouee, M., Amoozgar, H., and Haghpanah, S. Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia. View abstract. J Pediatr 1982;101:782-5. Goldenberg, N. A., Krantz, M. J., and Hiatt, W. R. L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. Medically reviewed by Drugs.com on Jun 6, 2022. Eur J Heart Fail. 2008;23(7):1602-1606. Torrioli, M. G., Vernacotola, S., Mariotti, P., Bianchi, E., Calvani, M., De Gaetano, A., Chiurazzi, P., and Neri, G. Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome. Noble S, Goa KL. J Am Coll Nutr. Diabetologia 1997;40(1):A32. Support Care Cancer. 11-15-2008;102(10):1413-1417. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Clin Ther 1995;17:176-85. Davini P, Bigalli A, Lamanna F, Boem A. Hooshmand, S., Balakrishnan, A., Clark, R. M., Owen, K. Q., Koo, S. I., and Arjmandi, B. H. Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Duranay, M., Akay, H., Yilmaz, F. M., Senes, M., Tekeli, N., and Yucel, D. Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. View abstract. J Diabetes Complications 1999;13:251-3. View abstract. Zhao, J. L., Gao, D. Z., Liu, D., He, H. H., She, Q., and Yin, Y. H. Improvement of exercise tolerance by L-carnitine in patients with cardiac syndrome X. Chin.Hosp.Pharm.J. Acta Chir Scand Suppl 1983;517:157-164. Four weeks of taking supplements did not increase fat burning (28). Trivelli G, Vitali P Girmenia S Castelli F. Trattamento della dislipidemia dell'emodializzato con L-carnitina. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. View abstract. Martinotti, G., Reina, D., Di, Nicola M., Andreoli, S., Tedeschi, D., Ortolani, I., Pozzi, G., Iannoni, E., D'Iddio, S., and Janiri, L. Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: a randomized, double-blind, placebo-controlled pilot trial. Moncada ML, Vicari E, Cimino C, et al. Are There Side Effects to L-Carnitine Supplementation? View abstract. View abstract. The liquid medicine can be taken alone or mixed with a beverage or soft food. Ann.Hematol. Yang, L., Yin, H., Yang, R., and Huang, X. View abstract. Insomnia, headaches and vertigo are common side effects. View abstract. Control of valproate-induced hepatotoxicity with carnitine. Gynecol Endocrinol 2018;34(8):684-8. Sherif NA, El-Banna AS, ElBourini MM, Khalil NO. Drugs Exp Clin Res 1992;18(4):147-153. A healthy individual can also produce sufficient amounts within the body. View abstract. View abstract. J Clin Endocrinol Metab. Ramos AC, Elias PR, Barrucand L, Da Silva JA. Xue, Y. Bonavita, E. Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain. OTHER NAMES(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, OTHER NAME(S): 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminiu, L-carnitine is a chemical that is made in the human. View abstract. Brevetti G, Perna S, Sabba C, et al. Sunamori M, Nakagawa T, Fujisawa S, and et al. 2000;2(2):189-193. View abstract. J Inherit.Metab Dis 2008;31 Suppl 2:S219-S222. Blood 1998;91:3817-24. You may report side effects to FDA at 1-800-FDA-1088. 2010;78(2):191-194. 2010;42(10):1809-1818. Interventions for treating leg ulcers in people with sickle cell disease. View abstract. Dev Med Child Neurol 1991;33:795-802. Eur.Urol. Kahn J, Lagakos S, Wulfsohn M, et al. A., Thelen, J. View abstract. View abstract. 1986;13(6):268-276. View abstract. Int Urol Nephrol 2021;53(10):2149-2158. Evaluation of torvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial. Garzya G, Corallo D, Fiore A, et al. The role of oral L-carnitine therapy in chronic hemodialysis patients. Rossignol, D. A. 1992;14(4):183-194. Greig, C., Finch, K. M., Jones, D. A., Cooper, M., Sargeant, A. J., and Forte, C. A. Intern.Med 2010;49(16):1717-1725. Larsson, L. E., Olegard, R., Ljung, B. M., Niklasson, A., Rubensson, A., and Cederblad, G. Parenteral nutrition in preterm neonates with and without carnitine supplementation. View abstract. View abstract. The therapeutic effect of L-carnitine in patients with exercise-induced stable angina: a controlled study. Specific populations may benefit from L-carnitine supplements. Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital. J Clin Oncol. Skip the missed dose if it is almost time for your next scheduled dose. Metabolism 2010;59(8):1190-1199. 2008;22(4):1130-1135. Villani, R. G., Gannon, J., Self, M., and Rich, P. A. L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women. Additional anti-ischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy. However, the human body is extremely complex, and the results of both human and animal studies are mixed (24, 25, 26, 27). Brand names: Carnitor, L-Carnitine Diabetes Res Clin Pract 1991;14:191-5. View abstract. Socha, P., Horvath, A., Vajro, P., Dziechciarz, P., Dhawan, A., and Szajewska, H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. View abstract. L-carnitines benefits may be indirect and take weeks or months to appear. View abstract. Here are 9 easy ways to boost your metabolism, backed by science. Heil, S. G., Hogeveen, M., Kluijtmans, L. A., van Dijken, P. J., van de Berg, G. B., Blom, H. J., and Morava, E. Marfanoid features in a child with combined methylmalonic aciduria and homocystinuria (CblC type). Karanth, J. and Jeevaratnam, K. Effect of dietary lipid, carnitine and exercise on lipid profile in rat blood, liver and muscle. "L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis." 10-21-2011;17(39):4414-4420. View abstract. View abstract. JPEN J Parenter.Enteral Nutr. Disclaimer: Go To See My Account. Iranian J.Nutr.Sci.Food Technol. Bohmer, T., Boen, A., and Hoymork, S. C. Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. Therapeutic Research Faculty 2018. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology 2003;47:94-7. Evangelista, M., Koverech, A., Messano, M., and Pescosolido, N. Comparison of three lubricant eye drop solutions in dry eye patients. Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis. View abstract. Am J Mens Health 2021;15(2):15579883211011371. Dimitriadis, F., Tsambalas, S., Tsounapi, P., Kawamura, H., Vlachopoulou, E., Haliasos, N., Gratsias, S., Watanabe, T., Saito, M., Miyagawa, I., and Sofikitis, N. Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial. Analysis of the full dataset has . Clinical and biochemical effects. L-carnitine supplementation vs cycle ergometer exercise for physical activity and muscle status in hemodialysis patients: a randomized clinical trial. Controlled study on L-carnitine therapeutic efficacy in post-infarction. Int J Clin Pharmacol Ther. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. Moretti S, Alesse E, Di Marzio L, et al. Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris. J Vasc.Surg. Curr Ther Res 1980;27(2):208-216. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. 2007;26(1):93-94. Some studies demonstrate a potential for reducing blood pressure and the inflammatory process associated with heart disease (23, 39). Exp Clin Endocrinol Diabetes. Int J Clin Pharmacol Res 1990;10:75-9. Epilepsia 1996;37:687-9. There are few negative side effects from this supplement at reasonable doses. Dragan, I. G., Vasiliu, A., Georgescu, E., and Eremia, N. Studies concerning chronic and acute effects of L-carnitina in elite athletes. L-carnitine may aid weight loss. View abstract. J Inherit.Metab Dis 2006;29(5):631-636. 2011;93(4):799-808. View abstract. Neurol.India 2008;56(3):391-393. View abstract. U.S. Berthillier G, Eichenberger D, Carrier HN, et al. View abstract. Vicari E, La Vignera S, Calogero AE. J Pediatr 1981;98(6):976-978. Turk.J Pediatr 1998;40(1):79-84. Scand.J Clin Lab Invest 1985;45(3):193-198. Eur J Pediatr 1995;154:686-7. L-Carnitine: Types, benefits, and side effects - Medical News Today View abstract. View abstract. The effect of L-carnitine supplement on dialysis patients [abstract]. View abstract. Casciani CU, Caruso U, Cravotto E, and et al. Carnitine metabolism in early stages of Duchenne muscular dystrophy. Zhonghua Er.Ke.Za Zhi. This information may not fit your specific health circumstances. Casciani, C. U., Caruso, U., Cravotto, E., D'Iddio, S., Corsi, M., Pola, P., Savi, L., and Grilli, M. L-carnitine in haemodialysed patients. Saudi.J Kidney Dis Transpl. It can cause side effects such as nausea, vomiting, stomach upset, heartburn, diarrhea, and seizures. View abstract. L-Carnitine - A Review of Benefits, Side Effects and Dosage - Healthline L-carnitine supplements can incur side effects similar to those of most dietary supplements and medications. When taken by mouth: L-carnitine is likely safe when taken for up to 12 months. 2006;26(4):499-500. View abstract. Jing, L., Li, W. M., Zhou, L. J., and Song, J. View abstract. Carnitine supplementation in diphtheria. Yet, there are a few known side effects that include agitation, insomnia and nausea. Calabrese, V., Cornelius, C., Mancuso, C., Lentile, R., Stella, A. M., and Butterfield, D. A. Redox homeostasis and cellular stress response in aging and neurodegeneration. J Clin Rheumatol. J Ren Nutr 1998;8:118-21. Zhonghua Nan.Ke.Xue. Jung, J., Eo, E., and Ahn, K. O. Int J Clin Pharmacol Res 1990;10:355-60. 2010;54(1):37-44. In an eight-week study in 38 women who exercised four times per week, there was no difference in weight loss between those who took L-carnitine and those who didnt (24). Biol.Neonate 1987;51(4):185-193. Ren Fail. 2010;34(3):295-299. Healthline Media does not provide medical advice, diagnosis, or treatment. J Inherit.Metab Dis 2009;32(4):488-497. Kavukcu, S., Turkmen, M., Salman, S., Onvural, B., Oktay, G., Karaman, O., and Cevik, N. T. The effects of L-carnitine on respiratory function tests in children undergoing chronic hemodialysis. Drugs R D 2002;3:223-31. Li, Z., Gu, R. H., Liu, Y., Xiang, Z. Q., Cao, X. R., Han, Y. F., Zhang, X. S., and Wang, Y. X. Curative effect of L-carnitine supplementation in the treatment of male infertility. Diabetologia 1995;38(1):123. Circ Rep 2019;1(11):508-516. Valproate therapy does not deplete carnitine levels in otherwise healthy children. Indian J Exp.Biol. Kotby, A. Sharifi, A. M., Zare, B., Keshavarz, M., and Ghaderpanahi, M. Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin-induced diabetic rats. Carnitor (levocarnitine) package insert. Eur J Gastroenterol Hepatol 2019;31(7):878-84. doi: 10.1097/MEG.0000000000001368. (Chinese) 2005;11:761-764. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. Pichard, C., Roulet, M., Rossle, C., Chiolero, R., Schutz, Y., Temler, E., Boumghar, M., Schindler, C., Zurlo, F., Jequier, E., and . Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali RA, Muscatello MR. Acetyl-L-Carnitine Augmentation of Clozapine in Partial-Responder Schizophrenia: A 12-Week, Open-Label Uncontrolled Preliminary Study. L-Carnitine L-Tartrate (LCLT) is typically used for physical performance and power output. Some research suggests that L-carnitine may help prevent or reduce symptoms of an overactive thyroid, such as insomnia, nervousness, heart palpitations, and tremors. 2010;21(3):454-459. A., Hatfield, D. L., Vingren, J. L., Quann, E. E., Anderson, J. M., Maresh, C. M., and Kraemer, W. J. 2006;8(5 Pt 1):503-507. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. It specifically emphasizes upon the beneficial role of l-carnitine in cardiomyopathy. View abstract. Martinotti, G., Andreoli, S., Reina, D., Di, Nicola M., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., and Prof, L. J. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Long-term l-carnitine treatment of chronic anaemia of patients with end-stage renal failure. Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ. Propionyl carnitine in stable effort angina. eCollection 2019. View abstract. L-Carnitine Side Effects: Common, Severe, Long Term - Drugs.com Maccio, A., Madeddu, C., Gramignano, G., Mulas, C., Floris, C., Sanna, E., Cau, M. C., Panzone, F., and Mantovani, G. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life. [The anti-arrhythmic effect of L-carnitine in subjects with ischemic cardiopathy]. JPEN J Parenter.Enteral Nutr. L-carnitine specifically acetyl-L-carnitine can have beneficial effects on brain function in various diseases. CNS.Drugs 2007;21 Suppl 1:25-30. Phillips, T. J., Cherry, C. L., Cox, S., Marshall, S. J., and Rice, A. S. Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials. 2014 Feb;99(2):408-22. AIDS Res.Hum.Retroviruses 2010;26(11):1207-1214. Gheissari A, Aslani N, Eshraghi A, et al. View abstract. Calo, L. A., Pagnin, E., Davis, P. A., Semplicini, A., Nicolai, R., Calvani, M., and Pessina, A. C. Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. J Inherit.Metab Dis 6-15-2010; View abstract. El-Beshlawy, A., El, Accaoui R., Abd El-Sattar, M., Gamal El-Deen, M. H., Youssry, I., Shaheen, N., Hamdy, M., El-Ghamrawy, M., and Taher, A. L-carnitine supplementation in childhood epilepsy: Current perspectives. Vaux, E. C., Taylor, D. J., Altmann, P., Rajagopalan, B., Graham, K., Cooper, R., Bonomo, Y., and Styles, P. Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease. Andrologia. 2014 Jul 12;12:65. Sima AAF, Calvani M, Mehra M, et al. Cao, Y., Wang, Y. X., Liu, C. J., Wang, L. X., Han, Z. W., and Wang, C. B. J Gastroenterol. B., Lagler, F., Maier, E. M., Schwahn, B., Tokatli, A., Dursun, A., Coskun, T., Chalmers, R. A., Koeller, D. M., Zschocke, J., Christensen, E., Burgard, P., and Hoffmann, G. F. Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency. Cherchi A, Lai C, Angelino F, et al. Hum Reprod Update 1996;2:87-102. Gesuete, V., Ragni, L., and Picchio, F. M. [The "big heart" of carnitine]. View abstract. Clin Invest Med. Int J Clin Pharmacol Res 1990;10:101-7. View abstract. Semin Perinatol 1999;23:152-61. Carnitine is naturally present in many foodsespecially foods of animal originand is available as a dietary supplement. . Hepatology 2010;52(1):79-104. View abstract. 2013;38(1):31-41. Ann Neurol 1994;35:482-7. Scand.J Gastroenterol. View abstract. View abstract. Follow all directions on your medicine label and package. Bartels GL, Remme WJ, Pillay M, et al. How can you boost your metabolism? Clin Exp.Hypertens. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. Rolim LC, da Silva EM, Flumignan RL, Abreu MM, Dib SA. These symptoms are not considered to be severe side effects. Novel and emerging treatments for autism spectrum disorders: a systematic review. Am J Med 2001;110:616-22.. View abstract. (20,39) Call your doctor at once if you have: a seizure (convulsions). Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects. L-carnitine is LIKELY SAFE when taken by mouth for up to 12 months, and when used as an injection, with the approval of a healthcare provider. Baudouin C, Labb A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. The main dietary sources of L-carnitine are meat, fish and some other animal products, such as milk. Brass E. Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients. Abbasnezhad A, Choghakhori R, Kashkooli S, Alipour M, Asbaghi O, Mohammadi R. Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis. (More information) If you choose to take L-carnitine supplements, the Linus Pauling Institute recommends acetyl-L-carnitine at a daily dose of 0.5 to 1 g. View abstract. Huidekoper, H. H., Schneider, J., Westphal, T., Vaz, F. M., Duran, M., and Wijburg, F. A. Desbree, A., Houdon, L., Touati, G., Djemili, S., Choker, G., and Flodrops, H. [EBV infection revealing a long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency in a 3-year-old boy]. Pediatr.Res 1982;16(2):89-91. View abstract. AIDS 2004;18:1549-60. Drugs Exp Clin Res 1990;16:101-6. View abstract. View abstract. J Int.Soc.Sports Nutr. Fertil.Steril. View abstract. View abstract. View abstract. View abstract. J Pain Symptom Manage 2006;32:551-9. B., and Wang, Y. X. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. Effect of L-carnitine on the limitation of infarct size in one-month postmyocardial infarction cases. 2011;6(1):23-32. A., Burlina, A. Ohtani Y, Endo F, Matsuda I. Carnitine deficiency and hyperammonemia associated with valproic acid therapy. Cardiovasc.Drugs Ther 2012;26(5):401-408. View abstract. 2010;68(5):743-752. J Am Coll Nutr. Biochem Pharmacol 1995;49:1403-10. Zhou, X., Liu, F., and Zhai, S. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. [A systematic review of the effectiveness of alternative weight-loss products' ingredients]. Clinical Trials Journal 1986;23(6):338-344. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Effect of l-carnitine supplementation on children and adolescents with nonalcoholic fatty liver disease (NAFLD): a randomized, triple-blind, placebo-controlled clinical trial. Horvath, G. A., Davidson, A. G., Stockler-Ipsiroglu, S. G., Lillquist, Y. P., Waters, P. J., Olpin, S., Andresen, B. S., Palaty, J., Nelson, J., and Vallance, H. Newborn screening for MCAD deficiency: experience of the first three years in British Columbia, Canada. View abstract. 2020;39(5):457-468. Andrologia 1994;26(3):155-159. Spiekerkoetter, U., Bastin, J., Gillingham, M., Morris, A., Wijburg, F., and Wilcken, B. Gut. Ellaway CM, Williams K, Leonard H, et al. J Med.Food 2006;9(4):468-473. Hiatt WR, Regensteiner JG, Creager MA, et al. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. Molyneux, R., Seymour, A. M., and Bhandari, S. Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies. Drugs Exp Clin Res 1999;25:29-36. Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II. Trovato GM, Ginardi V, Di Marco V, and et al. View abstract. View abstract. View abstract. J Endocrinol.Invest 2011;34(4):287-291. J Androl 2012;33(2):170-175. L-Carnitine may cause serious side effects. Gunal, A. I., Celiker, H., Donder, E., and Gunal, S. Y. View abstract. View abstract. Intensive Care Med. Pueschel, S. M. The effect of acetyl-L-carnitine administration on persons with Down syndrome. Even higher doses may cause insomnia. L-carnitine may increase the risk of seizures in those with epilepsy. View abstract. But athletes use acetyl-l-carnitine as a handy supplement to improve focus, mental energy, and even sleep. View abstract. A pilot study. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. View abstract. Do not take extra medicine to make up the missed dose. (Paris) 2010;166(3):289-294. View abstract. View abstract. Abdollahi H, Abdolahi M, Sedighiyan M, Jafarieh A. Drugs Exper Clin Res 1983;9:925-934. 2003;21(3):271-275. These include: stomach cramps nausea vomiting diarrhea Some. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. View abstract. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma- butyrobetaine hydroxylase inhibitor. View abstract. J.Med.Sci. Ishikura H, Matsuo N, Matsubara M, et al. View abstract. Shi, J. Side effects may include nausea, gastrointestinal discomfort, bloating, diarrhea, hives, lower back pain, leg restlessness, numbness, rash, endocrine changes, increased inflammatory response, increased blood urea nitrogen, severe tissue necrosis and venous irritation. Ther Apher Dial 2020. Clin Ter. Ann.Clin Psychiatry 2009;21(4):213-236.